沉默原肌球蛋白-1 可阻断在位子宫内膜中 PDGF 诱导的增殖。
Silencing Cofilin-1 blocks PDGF-induced proliferation in eutopic endometrium of endometriosis patients.
机构信息
Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, 36 Sanhao Street, Shenyang, 110004, China.
出版信息
Cell Biol Int. 2013 Aug;37(8):799-804. doi: 10.1002/cbin.10093. Epub 2013 Apr 11.
Platelet-derived growth factor (PDGF) is well known to induce proliferation in variety of cells. The aim of this study was to investigate whether there is a correlation between the expression of Cofilin-1 (CFL1) and the proliferation of eutopic endometrium stromal cells (ESC) in response to PDGF stimulation. Results show that PDGF induced the expression of CFL1 in ESC and promoted proliferation of ESC significantly in a time- or dose-dependent manner. After silencing CFL1, the effect of PDGF on promoting ESC proliferation was significantly decreased. These data demonstrate that PDGF can induce CFL1 expression in ESC. Silencing CFL1 blocks PDGF-induced proliferation in ESC.
血小板衍生生长因子（PDGF）是众所周知的能够诱导多种细胞增殖。本研究旨在探讨肌动蛋白结合蛋白-1（CFL1）的表达与在位子宫内膜基质细胞（ESC）对 PDGF 刺激的增殖之间是否存在相关性。结果表明，PDGF 诱导 ESC 中 CFL1 的表达，并以时间或剂量依赖的方式显著促进 ESC 的增殖。沉默 CFL1 后，PDGF 促进 ESC 增殖的作用明显降低。这些数据表明 PDGF 可以诱导 ESC 中 CFL1 的表达。沉默 CFL1 可阻断 PDGF 诱导的 ESC 增殖。
Zotero 插件