钛植入物中形成的骨非胶原蛋白的分离：在兔胫骨中使用骨采集腔的实验研究。

Separation of non-collagenous proteins of bone formed in titanium implants: experimental study in the rabbit tibia, using a bone harvest chamber.

作者信息

Lundgren T, Sennerby L

机构信息

Department of Oral Biochemistry, Gothenburg University, Sweden.

出版信息

Biomaterials. 1990 Apr;11(3):216-8. doi: 10.1016/0142-9612(90)90158-m.

DOI:10.1016/0142-9612(90)90158-m

PMID:2350560

Abstract

The non-collagenous proteins of mature cortical rabbit bone and 3 wk old bone specimens formed in titanium implant bone harvest chambers, were separated by means of fine pressure liquid chromatography. It was found that a sufficient amount of bone could be obtained from five bone harvest chambers in five rabbits during a period of 15 wk. A different protein chromatographic pattern was found in bone grown in bone harvest chambers as compared to normal cortical bone from the same region. This indicates a difference in bone quality and shows that this implant design can be used for biochemical analysis of bone formed adjacent to a biomaterial.

摘要

采用精细压力液相色谱法对成熟兔皮质骨以及在钛植入物骨采集腔中形成的3周龄骨标本的非胶原蛋白进行分离。结果发现，在15周的时间里，可以从5只兔子的5个骨采集腔中获得足够量的骨。与同一区域的正常皮质骨相比，在骨采集腔中生长的骨呈现出不同的蛋白质色谱图谱。这表明骨质量存在差异，并表明这种植入物设计可用于对生物材料邻近部位形成的骨进行生化分析。