2型糖尿病患者血浆中CXCL1（GRO-α）和CXCL10（IP-10）水平升高：炎症和血管生成/血管抑制参与此疾病状态的证据。
Plasma levels of CXCL1 (GRO-alpha) and CXCL10 (IP-10) are elevated in type 2 diabetic patients: evidence for the involvement of inflammation and angiogenesis/angiostasis in this disease state.
作者信息
Sajadi Seyyed Mohamad Ali, Khoramdelazad Hossein, Hassanshahi Gholamhossein, Rafatpanah Houshang, Hosseini Javad, Mahmoodi Mehdi, Arababadi Mohammad Kazemi, Derakhshan Reza, Hasheminasabzavareh Roshanak, Hosseini-Zijoud Seyed-Mostafa, Ahmadi Zahra
机构信息
Department of Internal Medicine, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
出版信息
Clin Lab. 2013;59(1-2):133-7. doi: 10.7754/clin.lab.2012.120225.
BACKGROUND
Recent evidence has demonstrated that environment and genetic factors play pivotal roles in diabetes and its related complications. The significant contributory role of cytokines in pathogenesis of type 2 diabetes is also well documented. This study was aimed to examine and compare both CXCL1 (GRO-alpha) and CXCL10 (IP-10) circulating levels in type 2 diabetic patients and healthy controls.
METHODS
Peripheral blood samples were collected from 100 type 2 diabetic patients and 150 healthy controls. Circulating CXCL1 and CXCL10 levels were measured by ELISA.
RESULTS
Elevated serum levels of both CXCL1 and CXCL10 were found in type 2 diabetic patients in comparison to controls.
CONCLUSIONS
Elevated levels of CXCL1 and CXCL10 could possibly be used as a marker of inflammation and angiogenesis/angiostasis in type 2 diabetes.
背景
最近的证据表明，环境和遗传因素在糖尿病及其相关并发症中起关键作用。细胞因子在2型糖尿病发病机制中的重要作用也有充分记录。本研究旨在检测和比较2型糖尿病患者和健康对照者的循环CXCL1（GRO-α）和CXCL10（IP-10）水平。
方法
收集100例2型糖尿病患者和150例健康对照者的外周血样本。采用ELISA法检测循环CXCL1和CXCL10水平。
结果
与对照组相比，2型糖尿病患者血清CXCL1和CXCL10水平均升高。
结论
CXCL1和CXCL10水平升高可能作为2型糖尿病炎症和血管生成/血管稳态的标志物。
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