CXCL9/CXCL10 angiostasis CXC-chemokines in parallel with the CXCL12 as an angiogenesis CXC-chemokine are variously expressed in pre-eclamptic-women and their neonates.

BACKGROUND

The disorder of pre-eclampsia is described as a complicated gestational state in which some of bio-molecules, including cytokines and chemokines are involved. The main purpose of the current study was examining of the circulating levels of CXCL9, CXCL10 as inducible, angiostasis chemokines as well as CXCL12 as an angiogenesis, homeostatic chemokine, in pregnant women with and without pre-eclampsia and their neonates.

METHODS

Peripheral blood and cord samples were collected from 53 preeclampsia patients and 53 normal pregnant women without preeclampsia and their related neonates. The differences in serum levels of CXCL9, CXCL10 and CXCL12 and the placental tissue expression of these chemokines were investigated by ELISA and western blot analysis, respectively.

RESULTS

Findings of the present study demonstrated that the levels of CXCL9 chemokine in parallel with CXCL12 as homeostatic chemokine were induced in pre-eclamptic women compared with normal pregnant women while CXCL10 remained unchanged. The CXCL9 and CXCL10 were both decreased in neonates who were delivered by pre-eclamptic women in compare to normal pregnant women. A CXCL12 level was elevated in neonates and has followed a similar fashion as mothers.

CONCLUSION

According to the results, the CXC chemokines are involved in pathogenesis of pre-eclampsia and play important roles in several processes such as neovascularization, embryonic development and inflammatory responses that are mediated by pre-eclampsia.