The arcuate nucleus of hypothalamus mediates low but not high frequency electroacupuncture analgesia in rats.

Electrolytic, kainic acid or sham lesions were made in the arcuate nucleus of the hypothalamus (ARH) in female Wistar rats to investigate the putative role of the ARH in the organization of low (2 Hz) or high (100 Hz) frequency electroacupuncture (EA) analgesia. Both electrolytic and chemical lesions lead to an almost total suppression of the low frequency EA analgesia as measured 4 and 6 days following the surgical intervention, leaving high frequency EA analgesia unaffected. In sham-operated animals, the antinociceptive effect induced by low or high frequency EA was essentially intact. These data indicate that neurones of the ARH most likely play an important role in mediating low, but not high frequency EA analgesia.