SLC24 基因家族的 Na⁺/Ca²⁺-K⁺ 交换器：从视觉和嗅觉到记忆巩固和皮肤色素沉着。

The SLC24 gene family of Na⁺/Ca²⁺-K⁺ exchangers: from sight and smell to memory consolidation and skin pigmentation.

机构信息

Department of Physiology & Pharmacology, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Canada AB T2N 4N1.

出版信息

Mol Aspects Med. 2013 Apr-Jun;34(2-3):455-64. doi: 10.1016/j.mam.2012.07.008.

DOI:10.1016/j.mam.2012.07.008

PMID:23506883

Abstract

Members of the SLC24 gene family encode K(+)-dependent Na(+)/Ca(2+) exchangers (NCKX) that utilize both the inward Na(+) and outward K(+) gradients to extrude Ca(2+) from cells. There are five human SLC24 genes that play a role in biological process as diverse as vision in retinal rod and cone photoreceptors, olfaction, skin pigmentation and at least three of the five genes are also widely expressed in the brain. Here I review the functional, physiological and structural features of NCKX proteins that have emerged in the past few years.

摘要

SLC24 基因家族的成员编码依赖 K(+)的 Na(+)/Ca(2+)交换体 (NCKX)，它利用内向的 Na(+)和外向的 K(+)梯度将 Ca(2+)从细胞中排出。人类有五个 SLC24 基因，在视网膜视杆和视锥光感受器的视觉、嗅觉、皮肤色素沉着等多种生物学过程中发挥作用，其中至少有三个基因也广泛表达于大脑中。在这里，我回顾了过去几年中出现的 NCKX 蛋白的功能、生理和结构特征。