Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.
Mol Aspects Med. 2013 Apr-Jun;34(2-3):693-701. doi: 10.1016/j.mam.2012.07.014.
Riboflavin, a water-soluble vitamin also known as vitamin B2, is essential for normal cellular functions. Riboflavin transporters play important roles in its homeostasis. Recently, three novel riboflavin transporters were identified, and designated as RFT1, RFT2 and RFT3. Because the RFTs did not show similarity to other SLC transporters, and RFT1 and RFT3 are similar in sequence and function, they were assigned into a new SLC family, SLC52. Subsequently, RFT1/GPR172B, RFT3/GPR172A and RFT2/C20orf54 were renamed as RFVT1/SLC52A1, RFVT2/SLC52A2 and RFVT3/SLC52A3, respectively. In this review, we summarize recent findings on the cloning, nomenclature, functional characterization and genetic diseases of RFVT1/SLC52A1, RFVT2/SLC52A2 and RFVT3/SLC52A3.
核黄素，一种水溶性维生素，也被称为维生素 B2，是正常细胞功能所必需的。核黄素转运蛋白在其体内平衡中发挥重要作用。最近，发现了三种新型核黄素转运蛋白，并将其命名为 RFT1、RFT2 和 RFT3。由于 RFTs 与其他 SLC 转运蛋白没有相似性，并且 RFT1 和 RFT3 在序列和功能上相似，因此它们被归入一个新的 SLC 家族 SLC52。随后，RFT1/GPR172B、RFT3/GPR172A 和 RFT2/C20orf54 分别被重新命名为 RFVT1/SLC52A1、RFVT2/SLC52A2 和 RFVT3/SLC52A3。在这篇综述中，我们总结了 RFVT1/SLC52A1、RFVT2/SLC52A2 和 RFVT3/SLC52A3 的克隆、命名、功能特征和遗传疾病的最新发现。
