Deschênes M, Hu B
Centre de Recherche en Neurobiologie, Faculté de Médecine, Université Laval, Quebec, Canada.
Brain Res. 1990 Apr 16;513(2):339-42. doi: 10.1016/0006-8993(90)90478-t.
The synaptic response induced in thalamic relay cells by stimulation of peribrachial cholinergic afferents was studied in cats maintained under urethane anesthesia. Recordings were performed in the ventral lateral nucleus after destruction of the reticular thalamic complex and cortical lesion. Some animals were also pretreated with reserpine (1.2 mg/kg) 24 h before recording sessions. Repetitive stimulation (25-60 Hz for 200-600 ms) of the peribrachial area produced a slow depolarization and tonic firing in thalamic cells. The depolarization was associated with an increase in membrane resistance and its amplitude decreased during membrane hyperpolarization. The reactivity of thalamic relay cells to a corticothalamic volley was also increased during the slow depolarization. Similar results were obtained in reserpinized animals. On the basis of previous data obtained in vitro, it is concluded that the slow depolarization resulted from the activation of muscarinic receptors by brainstem cholinergic afferents.
在氨基甲酸乙酯麻醉的猫身上，研究了刺激臂周胆碱能传入纤维在丘脑中继细胞中诱导的突触反应。在破坏丘脑网状复合体和皮层损伤后，于腹外侧核进行记录。一些动物在记录前24小时还用利血平（1.2毫克/千克）进行了预处理。对臂周区域的重复刺激（25 - 60赫兹，持续200 - 600毫秒）在丘脑细胞中产生了缓慢去极化和紧张性放电。去极化与膜电阻增加有关，并且在膜超极化期间其幅度减小。在缓慢去极化期间，丘脑中继细胞对皮质丘脑冲动的反应性也增加。在使用利血平处理的动物中也获得了类似结果。根据先前在体外获得的数据，得出结论：缓慢去极化是由脑干胆碱能传入纤维激活毒蕈碱受体所致。
