通过非还原性二糖和三糖实现 CuAAC 介导的氨基糖苷-精氨酸缀合物模拟物的多样化。
CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides.
机构信息
Leibniz-Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, 06120 Halle, Germany.
出版信息
Carbohydr Res. 2013 Apr 19;371:61-7. doi: 10.1016/j.carres.2013.02.003. Epub 2013 Feb 24.
PMID:23507494
Abstract
Di- and triguanidinylation of trehalose, sucrose, and melizitose has been achieved via a Huisgen-cycloaddition approach. They can serve as aminoglycoside-arginine conjugate mimics, which has been demonstrated by their biological profiles in assays against Bacillus subtilis. For comparative studies, tetraguanidinylated neamine and kanamycin derivatives have also been synthesized and evaluated.
摘要
二胍基和三胍基衍生物通过霍夫曼环加成反应合成了海藻糖、蔗糖和麦枣糖。这些衍生物可以作为氨基糖苷-精氨酸的模拟物，这一点已通过它们在枯草芽孢杆菌测定中的生物特征得到证实。为了进行比较研究，还合成并评估了四胍基化的新霉素和卡那霉素衍生物。
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