Hiremath Vishwanath P, Rao C Bhasker, Naik Vijaya, Prasad Kakrala Veera
Department of Public Health Dentistry, Maratha Mandal Dental College, Karnataka, India.
Oral Health Prev Dent. 2013;11(1):61-9. doi: 10.3290/j.ohpd.a29377.
To assess the anti-inflammatory effect of vitamin D on gingivitis at various doses.
In this randomized controlled trial, daily oral vitamin D supplementation was given in doses of 2000 IU for group A, 1000 IU for group B, 500 IU for group C and a placebo for group D over a 3-month period. The changes in gingival scores were measured after the 1st, 2nd and 3rd months.
The gingivitis score changed in direct proportion to the dose of vitamin D supplementation. In group A, the mean gingival scores were 2.4 (baseline), 1.7 after the first month, 0.8 after the second month and 0.3 after the third month. The group B mean baseline gingival score of 2.3 decreased to 2.0 in the first month, 1.1 after the second month and 0.5 after the third month. In group C, the baseline gingival scores were 2.2 and 1.9 after one month, 1.4 after two months and 0.8 by the last visit. Comparing baseline gingivitis scores with the later-visit score using the Wilcoxon paired test, the significant anti-inflammatory effect was seen in group A after one month, in group B at two months and in group C at three months after oral vitamin D supplementation (P < 0.0001). However, group D did not show a significant antiinflammatory effect.
There is a dose-dependent anti-inflammatory effect of vitamin D on gingivitis. Vitamin D is a safe and effective anti-inflammatory agent in doses ranging from 500 IU to 2000 IU. Results are apparent earlier with the higher dose of 2000 IU.
评估不同剂量维生素D对牙龈炎的抗炎作用。
在这项随机对照试验中，A组每日口服2000国际单位维生素D，B组每日口服1000国际单位，C组每日口服500国际单位，D组服用安慰剂，为期3个月。在第1、2和3个月后测量牙龈分数的变化。
牙龈炎分数的变化与维生素D补充剂量成正比。A组的平均牙龈分数在基线时为2.4，第一个月后为1.7，第二个月后为0.8，第三个月后为0.3。B组的平均基线牙龈分数2.3在第一个月降至2.0，第二个月后为1.1，第三个月后为0.5。C组的基线牙龈分数在一个月后为2.2，两个月后为1.9，最后一次就诊时为1.4，末次随访时为0.8。使用Wilcoxon配对检验将基线牙龈炎分数与后期就诊分数进行比较，口服维生素D后，A组在一个月时、B组在两个月时、C组在三个月时观察到显著的抗炎作用（P<0.0001）。然而，D组未显示出显著的抗炎作用。
维生素D对牙龈炎有剂量依赖性抗炎作用。维生素D在500国际单位至2000国际单位的剂量范围内是一种安全有效的抗炎剂。2000国际单位的高剂量结果出现得更早。
