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本文引用的文献

1
Vitamin D and inflammatory diseases.维生素 D 与炎症性疾病。
J Inflamm Res. 2014 May 29;7:69-87. doi: 10.2147/JIR.S63898. eCollection 2014.
2
1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.1,25-二羟基维生素D3与白细胞介素-2联合抑制T细胞炎性细胞因子的产生,并促进表达细胞毒性T淋巴细胞相关抗原4(CTLA-4)和叉头框蛋白3(FoxP3)的调节性T细胞的发育。
J Immunol. 2009 Nov 1;183(9):5458-67. doi: 10.4049/jimmunol.0803217.
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Issues in outcomes research: an overview of randomization techniques for clinical trials.结果研究中的问题:临床试验随机化技术概述
J Athl Train. 2008 Apr-Jun;43(2):215-21. doi: 10.4085/1062-6050-43.2.215.
4
Pharmacokinetics of a single, large dose of cholecalciferol.单次大剂量胆钙化醇的药代动力学。
Am J Clin Nutr. 2008 Mar;87(3):688-91. doi: 10.1093/ajcn/87.3.688.
5
Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation.血清25-羟维生素D浓度与牙龈炎症之间的关联。
Am J Clin Nutr. 2005 Sep;82(3):575-80. doi: 10.1093/ajcn.82.3.575.
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Benefits and requirements of vitamin D for optimal health: a review.维生素D对最佳健康状态的益处及需求:综述
Altern Med Rev. 2005 Jun;10(2):94-111.
7
The effects of calcitriol therapy on serum interleukin-1, interleukin-6 and tumour necrosis factor-alpha concentrations in post-menopausal patients with osteoporosis.骨化三醇疗法对绝经后骨质疏松症患者血清白细胞介素-1、白细胞介素-6和肿瘤坏死因子-α浓度的影响。
J Int Med Res. 2004 Nov-Dec;32(6):570-82. doi: 10.1177/147323000403200602.
8
Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population.美国人群中血清25-羟基维生素D3浓度与牙周病之间的关联。
Am J Clin Nutr. 2004 Jul;80(1):108-13. doi: 10.1093/ajcn/80.1.108.
9
Efficacy of a fluoridated hydrogen peroxide-based mouthrinse for the treatment of gingivitis: a randomized clinical trial.含氟过氧化氢漱口水治疗牙龈炎的疗效:一项随机临床试验。
J Periodontol. 2004 Jan;75(1):57-65. doi: 10.1902/jop.2004.75.1.57.
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The relation of nutrition to periodontal disease.营养与牙周疾病的关系。
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一项评估维生素D对牙龈炎抗炎作用的研究:一项剂量依赖性随机对照试验。

A Study to Assess Anti-Inflammatory Effect of Vitamin D on Gingivitis: A Dose Dependent Randomised Controlled Trial.

作者信息

Srivastava Rahul, Raza Hadi, Kabra Pooja, Arya Ashtha, Purushothaman Athira, Thomas Pallavi A

机构信息

Department of Oral Medicine and Radiology, Rama Dental College, Kanpur, Uttar Pradesh, India.

Department of Public Health Dentistry, Yenepoya Dental College, Mangaluru, Karnataka, India.

出版信息

J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S1182-S1184. doi: 10.4103/jpbs.jpbs_169_23. Epub 2023 Jul 11.

DOI:10.4103/jpbs.jpbs_169_23
PMID:37694098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10485514/
Abstract

INTRODUCTION

Vitamin D deficiency increases gingivitis risk. Studies show that higher vitamin D levels reduce inflammation.

MATERIALS AND METHODS

College conducted a double-blind, randomized, controlled trial on 451 people's vitamin D and gingival health at baseline. For three months, participants were given a placebo (group A), 1000 international units (IU) of vitamin D3 per day (group B), 500 IU per day (group C), or 2000 IU per day (group A). Gingival scores were recorded for three months to assess the anti-inflammatory effect (the first, second, and third). Vitamin D levels also affected gingivitis.

RESULTS

Vitamin D dose-dependently reduces gingivitis inflammation. Vitamin D administration negatively correlated with gingival index score. Anti-inflammatory vitamin D levels are 32-37 ng/ml.

CONCLUSION

Vitamin D supplementation can reduce gingivitis severity. The optimal blood vitamin D level is 30-35 ng/ml.

摘要

引言

维生素D缺乏会增加患牙龈炎的风险。研究表明,较高的维生素D水平可减轻炎症。

材料与方法

某学院对451人在基线时的维生素D和牙龈健康状况进行了一项双盲、随机、对照试验。为期三个月,参与者被给予安慰剂(A组)、每天1000国际单位(IU)的维生素D3(B组)、每天500 IU(C组)或每天2000 IU(D组)。记录三个月的牙龈评分以评估抗炎效果(第一次、第二次和第三次)。维生素D水平也会影响牙龈炎。

结果

维生素D呈剂量依赖性地减轻牙龈炎炎症。补充维生素D与牙龈指数评分呈负相关。抗炎的维生素D水平为32 - 37 ng/ml。

结论

补充维生素D可减轻牙龈炎的严重程度。最佳血液维生素D水平为30 - 35 ng/ml。