一项评估维生素D对牙龈炎抗炎作用的研究：一项剂量依赖性随机对照试验。
A Study to Assess Anti-Inflammatory Effect of Vitamin D on Gingivitis: A Dose Dependent Randomised Controlled Trial.
作者信息
Srivastava Rahul, Raza Hadi, Kabra Pooja, Arya Ashtha, Purushothaman Athira, Thomas Pallavi A
机构信息
Department of Oral Medicine and Radiology, Rama Dental College, Kanpur, Uttar Pradesh, India.
Department of Public Health Dentistry, Yenepoya Dental College, Mangaluru, Karnataka, India.
出版信息
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S1182-S1184. doi: 10.4103/jpbs.jpbs_169_23. Epub 2023 Jul 11.
INTRODUCTION
Vitamin D deficiency increases gingivitis risk. Studies show that higher vitamin D levels reduce inflammation.
MATERIALS AND METHODS
College conducted a double-blind, randomized, controlled trial on 451 people's vitamin D and gingival health at baseline. For three months, participants were given a placebo (group A), 1000 international units (IU) of vitamin D3 per day (group B), 500 IU per day (group C), or 2000 IU per day (group A). Gingival scores were recorded for three months to assess the anti-inflammatory effect (the first, second, and third). Vitamin D levels also affected gingivitis.
RESULTS
Vitamin D dose-dependently reduces gingivitis inflammation. Vitamin D administration negatively correlated with gingival index score. Anti-inflammatory vitamin D levels are 32-37 ng/ml.
CONCLUSION
Vitamin D supplementation can reduce gingivitis severity. The optimal blood vitamin D level is 30-35 ng/ml.
引言
维生素D缺乏会增加患牙龈炎的风险。研究表明，较高的维生素D水平可减轻炎症。
材料与方法
某学院对451人在基线时的维生素D和牙龈健康状况进行了一项双盲、随机、对照试验。为期三个月，参与者被给予安慰剂（A组）、每天1000国际单位（IU）的维生素D3（B组）、每天500 IU（C组）或每天2000 IU（D组）。记录三个月的牙龈评分以评估抗炎效果（第一次、第二次和第三次）。维生素D水平也会影响牙龈炎。
结果
维生素D呈剂量依赖性地减轻牙龈炎炎症。补充维生素D与牙龈指数评分呈负相关。抗炎的维生素D水平为32 - 37 ng/ml。
结论
补充维生素D可减轻牙龈炎的严重程度。最佳血液维生素D水平为30 - 35 ng/ml。
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