Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan.
Pancreas. 2013 May;42(4):663-9. doi: 10.1097/MPA.0b013e318279bd66.
Kindlin-2 is a novel focal adhesion protein reported to be expressed in breast, lung, and gastric cancers. This study aimed to investigate the significance of kindlin-2 expression in pancreatic ductal adenocarcinomas (PDACs).
We performed immunohistochemical analysis on kindlin-2 on PDAC samples from 95 patients. We investigated the association between kindlin-2 expression and clinicopathological parameters of PDAC and the survival time of patients with PDAC who underwent pancreatectomy.
Kindlin-2 was highly expressed in the peritumoral stroma of PDACs. Stromal kindlin-2 expression was related to nodal metastasis (P = 0.03). Univariate analysis showed that patients with positive kindlin-2 expression had significantly shorter survival times than those with negative kindlin-2 expression (P = 0.01). In addition, multivariate analysis revealed that kindlin-2 expression was an independent factor of poor prognosis in patients with PDAC after R0 resection (RR = 2.15; P = 0.04).
Kindlin-2 expression in stromal components is significantly associated with poor prognosis of patients with PDAC, suggesting that kindlin-2 is a prognostic marker for patients with PDAC.
Kindlin-2 是一种新型黏着斑蛋白，据报道在乳腺癌、肺癌和胃癌中表达。本研究旨在探讨 Kindlin-2 表达在胰腺导管腺癌（PDAC）中的意义。
我们对 95 例 PDAC 样本进行了 Kindlin-2 的免疫组织化学分析。我们研究了 Kindlin-2 表达与 PDAC 的临床病理参数以及接受胰腺切除术的 PDAC 患者生存时间之间的关系。
Kindlin-2 在 PDAC 的瘤周基质中高度表达。基质 Kindlin-2 的表达与淋巴结转移相关（P = 0.03）。单因素分析显示，Kindlin-2 阳性表达的患者与 Kindlin-2 阴性表达的患者相比，生存时间明显缩短（P = 0.01）。此外，多因素分析显示，Kindlin-2 表达是 RO 切除后 PDAC 患者预后不良的独立因素（RR = 2.15；P = 0.04）。
基质成分中 Kindlin-2 的表达与 PDAC 患者的不良预后显著相关，提示 Kindlin-2 是 PDAC 患者的预后标志物。
