一种针对 HIV-1 蛋白酶的小分子试剂增强了 R5 HIV-1 分离物的体外复制。
Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease.
机构信息
Institute for Health Research and Policy, London Metropolitan University, 166-220 Holloway Rd, London N7 8DB, UK.
出版信息
ChemMedChem. 2013 May;8(5):719-21. doi: 10.1002/cmdc.201300051. Epub 2013 Mar 18.
PMID:23509042
Abstract
CHEMICAL ENHANCEMENT
Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.
摘要
化学增强
设计用于靶向 HIV-1 蛋白酶，一种新型 γ-羟膦酸酯已被发现可显著增强一组临床相关的 R5 HIV-1 分离物中的病毒复制。这一意外结果是首例能够做到这一点的小分子，这对疫苗和药物开发中 R5 分离物的制备和使用具有重要意义。
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