National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.
Org Lett. 2013 Apr 5;15(7):1614-7. doi: 10.1021/ol400393j. Epub 2013 Mar 19.
The first second-generation designer Ru(II) catalyst 1b featuring an enantiopure N,C-(N-ethylene-N-methyl-sulfamoyl)-tethered (DPEN-κ(2)N,N')/η(6)-toluene hybrid ligand is introduced. Using an S/C = 1000 in HCO2H-Et3N 5:2 transfer hydrogenation medium, secondary 1-naphthyl alcohols are obtained in up to >99.9% ee under mild conditions. Mechanistic factors are discussed.
引入了第一个第二代设计 Ru(II)催化剂 1b，其特征在于手性纯的 N，C-（N-乙烯基-N-甲基磺酰胺）-键合（DPEN-κ(2)N，N'）/η(6)-甲苯混合配体。在 S/C = 1000 的 HCO2H-Et3N 5:2 转移氢化介质中，在温和条件下，仲 1-萘基醇的ee 值高达>99.9%。讨论了机理因素。
