Mori M, Shimono R, Adachi Y, Matsuda H, Kuwano H, Sugimachi K, Ikeda M, Saku M
Division of Clinical Pathology, Kyushu University, Fukuoka, Japan.
Dis Colon Rectum. 1990 Jun;33(6):498-501. doi: 10.1007/BF02052146.
Mucosa adjacent to colorectal disease was studied mucin-histochemically. Selected specimens were also studied immunohistochemically for carcinoembryonic antigen (CEA). Transitional mucosa, which showed elongation of crypts and marked sialomucin secretion, accompanied by a marked reduction in the normal sulfomucin content, was evident in 96 of 100 carcinomas (96 percent), 18 of 36 adenomas (50 percent), and 10 of 30 metaplastic polyps (33 percent). When considering the appearance of transitional mucosa, not only in the neoplastic lesions such as carcinoma or adenoma but also in the begin polyp, the transitional change adjacent to the carcinoma cannot be classified as a precancerous phenomenon; rather, it is a secondary one. The mucin-histochemical study disclosed transitional mucosa in all the 21 carcinomas less than 1 cm in diameter and immunohistochemical staining for CEA showed no remarkable change in the adjacent mucosa. Thus, it seems apparent that a change in mucous secretion precedes that of CEA expression in the mucosa adjacent to the carcinoma.
对结直肠疾病邻近的黏膜进行了黏蛋白组织化学研究。还对选定的标本进行了癌胚抗原（CEA）免疫组织化学研究。100例癌中有96例（96%）、36例腺瘤中有18例（50%）、30例化生息肉中有10例（33%）可见过渡性黏膜，其特征为隐窝延长和大量涎黏蛋白分泌，同时正常硫黏蛋白含量显著减少。当考虑过渡性黏膜的出现情况时，不仅在癌或腺瘤等肿瘤性病变中，而且在起始息肉中，癌邻近的过渡性改变不能归类为癌前现象；相反，它是继发性的。黏蛋白组织化学研究在所有直径小于1 cm的21例癌中均发现了过渡性黏膜，CEA免疫组织化学染色显示邻近黏膜无明显变化。因此，似乎很明显，癌邻近黏膜中黏液分泌的变化先于CEA表达的变化。
