University of British Columbia, School of Engineering, Kelowna, BC, Canada.
Lab Chip. 2013 May 7;13(9):1823-30. doi: 10.1039/c3lc41292j.
This paper studies the effect of dielectrophoresis on particle manipulation and immobilization in digital microfluidic (DMF) devices. The dimensions of negative dielectrophoresis (nDEP) traps in the form of circular and square shapes are characterized using numerical and experimental approaches. These efforts will result in defining lifting and trapping zones, the ratio of which is shown to remain constant for trap sizes larger than 40 μm. As a result, a limiting constant K based on the ratio of the particle diameter to the trap size is introduced to identify the status of particle trapping prior to running numerical models or experiments. The results show that K must be less than 0.63 for trapping the particles on the nDEP traps. This study will also result in optimizing the trap size for single particle immobilization which is important for cell printing and growth applications.
本文研究了介电泳对数字微流控（DMF）装置中粒子操纵和固定的影响。采用数值和实验方法对圆形和方形负介电泳（nDEP）阱的尺寸进行了表征。这些工作将定义提升和捕获区，结果表明，对于大于 40 μm 的阱尺寸，该比值保持恒定。因此，引入了一个基于粒子直径与阱尺寸比的常数 K，以在运行数值模型或实验之前识别粒子捕获的状态。结果表明，K 必须小于 0.63，才能捕获 nDEP 阱上的粒子。本研究还将优化用于单细胞固定的阱尺寸，这对于细胞打印和生长应用很重要。
