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抗精神病药物长期治疗精神分裂症是否有助于康复？

Does long-term treatment of schizophrenia with antipsychotic medications facilitate recovery?

机构信息

Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL, USA.

出版信息

Schizophr Bull. 2013 Sep;39(5):962-5. doi: 10.1093/schbul/sbt034. Epub 2013 Mar 19.

DOI:10.1093/schbul/sbt034
PMID:23512950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3756791/
Abstract

Antipsychotic medications are viewed as cornerstones for both the short-term and long-term treatment of schizophrenia. However, evidence on long-term (10 or more years) efficacy of antipsychotics is mixed. Double-blind discontinuation studies indicate significantly more relapses in unmedicated schizophrenia patients in the first 6-10 months, but also present some potentially paradoxical features. These issues are discussed.

摘要

抗精神病药物被视为治疗精神分裂症短期和长期的基石。然而，关于抗精神病药物长期（10 年或更长时间）疗效的证据是混杂的。双盲停药研究表明，未经治疗的精神分裂症患者在最初的 6-10 个月内复发的风险显著增加，但也存在一些潜在的矛盾特征。这些问题将进行讨论。

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本文引用的文献

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Schizophr Bull. 2013 Nov;39(6):1296-306. doi: 10.1093/schbul/sbs130. Epub 2012 Nov 20.
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The research basis for Robert Whitaker's "Anatomy of an epidemic: magic bullets, psychiatric drugs and the astonishing rise of mental illness in America.罗伯特·惠特克的《流行病剖析：神奇子弹、精神药物与美国精神疾病惊人增长》的研究基础。
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Maintenance treatment with antipsychotic drugs for schizophrenia.使用抗精神病药物对精神分裂症进行维持治疗。
Cochrane Database Syst Rev. 2012 May 16(5):CD008016. doi: 10.1002/14651858.CD008016.pub2.
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Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis.抗精神病药物与安慰剂治疗精神分裂症复发的比较：系统评价和荟萃分析。
Lancet. 2012 Jun 2;379(9831):2063-71. doi: 10.1016/S0140-6736(12)60239-6. Epub 2012 May 3.
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Do all schizophrenia patients need antipsychotic treatment continuously throughout their lifetime? A 20-year longitudinal study.所有精神分裂症患者都需要终身持续接受抗精神病药物治疗吗？一项 20 年的纵向研究。
Psychol Med. 2012 Oct;42(10):2145-55. doi: 10.1017/S0033291712000220. Epub 2012 Feb 17.
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Remission and recovery during the first outpatient year of the early course of schizophrenia.首发精神分裂症早期门诊治疗阶段的缓解和康复。
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A scientific agenda for the concept of recovery as it applies to schizophrenia.适用于精神分裂症的康复概念的科学议程。
Clin Psychol Rev. 2008 Oct;28(7):1108-24. doi: 10.1016/j.cpr.2008.03.004. Epub 2008 Mar 18.
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World Psychiatric Association Pharmacopsychiatry Section statement on comparative effectiveness of antipsychotics in the treatment of schizophrenia.世界精神病学协会药物精神病学分会关于抗精神病药物治疗精神分裂症的比较疗效声明。
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