Department of Urology, Netherlands Cancer Institute , Amsterdam, The Netherlands .
J Endourol. 2013 Nov;27(11):1411-6. doi: 10.1089/end.2012.0735. Epub 2013 Aug 9.
Functional outcome and quality of life (QOL) domains are important outcomes after curative therapy for prostate cancer. Although useful for scientific purposes, QOL questionnaires may be too extensive for daily routine, and single questions or interview-assessed outcomes may be more practical alternatives. The QOL outcomes of these measures were compared.
The QOL of patients undergoing Robot-Assisted Radical Prostatectomy (RARP) in our hospital was monitored before and after treatment using both brief standardized interview questions, as well as more extensive validated questionnaires. The interview questions address erectile function and urinary continence with only one question on each subject (both four response items). Questionnaires included a total of 74 questions (EORTC-QLQ-C30, EORTC-QLQ-PR25, international index of erectile function-15, and international consultation on incontinence questionnaire-short form).
In 925 RARP patients, pre- and postoperative interview and questionnaire QOL data were available with a median follow up of 20 months. Improvement in both erectile function and continence scores occurred up till 2 years after the RARP for both interview- and questionnaire-based evaluations. On an individual patient basis, interview scores poorly correlated with questionnaire-based domains for continence and erectile function. Single questions from the questionnaire showed better correlation with domain scores. Functional recovery of continence after 1 year was worse when assessed by questionnaire than by interview evaluation. A decrease in physical (8%) and overall QOL (12%) after prostatectomy as assessed by the EORTC-QLQ-C30 questionnaire was better predicted by questionnaire-based than interview-based scores. Continence scores had a greater impact on physical and overall QOL scores than on erectile function scores.
Interview/assessed continence and erectile function outcome after RARP showed limited association with questionnaire-based evaluation and may overestimate functional recovery. Continence scores for both interviews and questionnaires were stronger correlated with physical and overall QOL than erectile function scores.
在根治性治疗前列腺癌后，功能结果和生活质量（QOL）领域是重要的结果。尽管 QOL 问卷对于科学目的很有用，但对于日常常规来说可能过于广泛，而单一问题或访谈评估的结果可能是更实用的替代方法。比较了这些措施的 QOL 结果。
我们医院接受机器人辅助根治性前列腺切除术（RARP）的患者在治疗前后使用简短的标准化访谈问题以及更广泛的经过验证的问卷来监测 QOL。访谈问题仅针对每个主题（每个主题都有四个回答项目）解决勃起功能和尿失禁问题。问卷包括总共 74 个问题（EORTC-QLQ-C30、EORTC-QLQ-PR25、国际勃起功能指数-15 和国际尿失禁咨询问卷-简短形式）。
在 925 例 RARP 患者中，可获得术前和术后访谈以及问卷 QOL 数据，中位随访时间为 20 个月。对于访谈和问卷评估，RARP 后 2 年内勃起功能和尿失禁评分均有所改善。在个体患者的基础上，访谈评分与问卷评估的尿失禁和勃起功能领域相关性较差。问卷中的单项问题与域评分的相关性更好。通过问卷评估的 1 年后的控尿功能恢复比访谈评估差。EORTC-QLQ-C30 问卷评估前列腺切除术后身体（8%）和总体 QOL（12%）下降的情况，通过问卷评分比通过访谈评分更好地预测。控尿评分对身体和总体 QOL 评分的影响大于对勃起功能评分的影响。
RARP 后访谈/评估的控尿和勃起功能结果与问卷评估相关性有限，可能高估了功能恢复。访谈和问卷的控尿评分与身体和总体 QOL 的相关性强于勃起功能评分。
