含丙二醇的日粮对猫乙酰氨基酚诱导的高铁血红蛋白血症的影响。

Effects of propylene glycol-containing diets on acetaminophen-induced methemoglobinemia in cats.

作者信息

Weiss D J, McClay C B, Christopher M M, Murphy M, Perman V

机构信息

Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108.

出版信息

J Am Vet Med Assoc. 1990 Jun 1;196(11):1816-9.

PMID:2351602

Abstract

Soft-moist cat foods contain 7 to 13% propylene glycol (PG) on a dry-weight basis. These diets induce Heinz body formation in feline RBC. In this study, we evaluated cats on a control diet and on a commercial diet containing 8.3% PG. All cats on the PG diet developed an increase in the number of circulating Heinz bodies. We then administered acetaminophen to cats on each diet to determine whether RBC from cats on PG diets were more susceptible to oxidant stress. Methemoglobin concentrations were significantly greater in cats in PG diets after acetaminophen administration. These data indicate that RBC from cats fed PG diets are more susceptible to oxidative stress.

摘要

软湿猫粮在干重基础上含有7%至13%的丙二醇（PG）。这些日粮会导致猫红细胞中形成海因茨小体。在本研究中，我们评估了食用对照日粮和含有8.3%PG的商业日粮的猫。所有食用含PG日粮的猫循环血液中的海因茨小体数量都有所增加。然后我们给每种日粮组的猫服用对乙酰氨基酚，以确定食用含PG日粮的猫的红细胞是否对氧化应激更敏感。服用对乙酰氨基酚后，含PG日粮组猫的高铁血红蛋白浓度显著更高。这些数据表明，食用含PG日粮的猫的红细胞对氧化应激更敏感。