[Effect of histamine on the hexokinase activity and RNA synthesis in the seminal vesicles and prostate of orchiectomized rats].

Due to orchidectomy, carried out two weeks before the experiment, in androgene-dependent rat tissues a hexokinase activity was found to be decreased several times. Within 24 hrs after administration of histamine into orchidectomized rats the hexokinase activity was increased by 96% in seminal follicles and by 160% in prostate. Incorporation of 3H-uridine into RNA of seminal follicles and prostate of castrated rat males was increased by 60% and 210%, respectively, within 3 hrs after the administration of histamine. The stimulating effects of histamine on RNA synthesis and the hexokinase activity were completely inhibited by actinomycin D. The data obtained suggest that histamine was one of mediators in the effect of testosterone on the tissues-targets.