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创伤后早期肺栓塞:一种不同的临床实体?

Early pulmonary embolism after injury: a different clinical entity?

作者信息

Benns Matthew, Reilly Patrick, Kim Patrick

机构信息

University of Pennsylvania, United States; University of Louisville, United States.

出版信息

Injury. 2014 Jan;45(1):241-4. doi: 10.1016/j.injury.2013.02.026. Epub 2013 Mar 19.

Abstract

BACKGROUND

We sought to characterize pulmonary embolism (PE) occurring early after injury. We hypothesized that early PE may represent a different clinical entity than those occurring later in the post-injury period.

METHODS

All trauma patients diagnosed with PE from 2005 to 2010 were examined. PEs diagnosed within 72h of admission were compared against those occurring later.

RESULTS

19 out of 54 PEs were diagnosed early. Early PE patients had a higher rate of lower extremity fractures, a lower mean injury severity score, and a lower average length of stay. Early PE patients had a shorter average time to start of chemical prophylaxis, were less likely to have had a femoral line, and less likely to have operative intervention under general anaesthesia.

CONCLUSIONS

Early PE after trauma may occur with different underlying pathophysiology than previously thought. Further study is indicated as this has implications concerning the prevention of PE in trauma patients.

摘要

背景

我们试图对受伤后早期发生的肺栓塞(PE)进行特征描述。我们假设早期肺栓塞可能代表一种与受伤后期发生的肺栓塞不同的临床实体。

方法

对2005年至2010年期间所有诊断为肺栓塞的创伤患者进行检查。将入院72小时内诊断出的肺栓塞与之后发生的肺栓塞进行比较。

结果

54例肺栓塞中有19例被早期诊断。早期肺栓塞患者下肢骨折发生率较高,平均损伤严重程度评分较低,平均住院时间较短。早期肺栓塞患者开始化学预防的平均时间较短,接受股静脉置管的可能性较小,接受全身麻醉下手术干预的可能性较小。

结论

创伤后早期肺栓塞可能具有与先前认为的不同的潜在病理生理学机制。鉴于这对创伤患者肺栓塞的预防具有影响,因此需要进一步研究。

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