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活性氧簇将葡萄糖代谢与乳腺癌干细胞和 EMT 表型联系起来。

ROS links glucose metabolism to breast cancer stem cell and EMT phenotype.

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

出版信息

Cancer Cell. 2013 Mar 18;23(3):265-7. doi: 10.1016/j.ccr.2013.02.021.

DOI:10.1016/j.ccr.2013.02.021
PMID:23518342
Abstract

Cancer stem cells display an epithelial-mesenchymal transition phenotype and are resistant to current therapies. In this issue of Cancer Cell, Dong and colleagues demonstrate that these phenotypes in basal-like breast cancer are promoted by a metabolic switch to glucose metabolism, resulting in decreased reactive oxygen species levels.

摘要

肿瘤干细胞表现出上皮-间充质转化表型，并对现有疗法具有抗性。在本期《癌细胞》杂志中，董等人表明，基底样乳腺癌中的这些表型是由代谢向葡萄糖代谢的转变所促进的，导致活性氧水平降低。

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