Institute for Cell Biology, University of Bonn, Bonn, Germany.
Autophagy. 2013 Jun 1;9(6):920-2. doi: 10.4161/auto.24213. Epub 2013 Mar 21.
Impairment of autophagy in patients and animal models severely affects mechanically strained tissues such as skeletal muscle, heart, lung and kidney, leading for example to muscle dystrophy, cardiomyopathy and renal injury. However, the reason for this high reliance on autophagy remained largely elusive. Recent work in our lab now provides a possible explanation. We identified chaperone-assisted selective autophagy (CASA) as a tension-induced autophagy pathway essential for mechanotransduction in mammalian cells.
自噬在患者和动物模型中的损伤严重影响了机械应变组织，如骨骼肌、心脏、肺和肾脏，导致例如肌肉萎缩症、心肌病和肾脏损伤。然而，这种对自噬的高度依赖的原因在很大程度上仍不清楚。我们实验室的最新研究现在提供了一个可能的解释。我们发现伴侣蛋白辅助的选择性自噬（CASA）是哺乳动物细胞中机械转导所必需的一种张力诱导的自噬途径。
