Institute of Pathology, Charité Hospital, Berlin, Germany.
Int J Gynecol Pathol. 2013 May;32(3):329-34. doi: 10.1097/PGP.0b013e3182625fec.
A 19-yr-old woman with previously diagnosed clear cell adenocarcinoma was referred to the Charité for further treatment. Biopsies were taken from the cervix, the endometrium, pseudomembranes in the peritoneum, and sentinel lymph nodes. The morphologic picture of pseudomembranes and inflammation together with the provided information about plasminogen deficiency of the patients led to the hypothesis of ligneous cervicitis. The previously taken biopsies of the adenocarcinoma were reevaluated and showed a clear cell lesion. Further immunohistochemical examination with antibodies against p16, Ki67, CEA, and p53 could not prove its malignant character. As a result we diagnosed an atypical form of microglandular hyperplasia in a patient with ligneous cervicitis. Ligneous cervicitis is a rare inflammatory condition that might affect all mucus membranes in patients with plasminogen deficiency. This case shows the importance of correlating pathologic and clinical findings in the diagnosis of ligneous cervicitis because of the rarity of the disease and the heterogeneity at presentation.
一位 19 岁的女性，此前被诊断为透明细胞腺癌，被转往 Charité 医院接受进一步治疗。宫颈、子宫内膜、腹膜假性膜和前哨淋巴结均取了活检。假性膜和炎症的形态学表现，加上患者纤溶酶原缺乏的信息，提示诊断为木质宫颈炎症。先前腺癌的活检再次评估显示出透明细胞病变。进一步用针对 p16、Ki67、CEA 和 p53 的免疫组化检查无法证明其恶性特征。因此，我们诊断为木质宫颈炎症伴不典型微小腺体增生。木质宫颈炎症是一种罕见的炎症性疾病，可能影响纤溶酶原缺乏患者的所有黏膜。由于该病罕见且临床表现多样，本病例表明在诊断木质宫颈炎症时，病理和临床发现的相关性非常重要。
