Chuntrasakul C, Tantibhedhyangkul P, Nimmanwudipong T
Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 1990 Feb;73(2):68-80.
To investigate the effectiveness of a new electrolyte solution, Glucolyte-2, which contains 7.5 per cent glucose, electrolytes, and a trace element (zinc), 12 postoperative surgical and 21 trauma patients who were unable to receive enteral feeding were given either Glucolyte-2 or the conventional infusion containing 5 per cent glucose and electrolytes as a control in a double-blind fashion. The zinc balance in surgical patients given Glucolyte-2 was 2.648 +/- 864 micrograms/day, whereas that in patients given the conventional infusion was -2,972 +/- 1,385 micrograms/day (mean +/- S.E.M.). The positive zinc balance after Glucolyte-2 administration was significantly higher than that after the conventional infusion (p less than 0.001). Similarly, a positive zinc balance (3,464 +/- 422 micrograms/day) was obtained in trauma patients given Glucolyte-2, while in trauma patients given the conventional infusion, the zinc balance was negative (-1,737 +/- 491 micrograms/day), which was significantly lower (p less than 0.05). Magnesium and phosphate balances were negative in surgical and trauma patients in both infusion groups. However, the balance in patients given Glucolyte-2 was better than in those patients given the conventional infusion. The differences of the balance for magnesium in surgical patients and trauma patients were significant (p less than 0.001 and p less than 0.01, respectively). The differences of the balance for phosphate in surgical and trauma patients were also significant (p less than 0.01). It is indicated that the infusion of Glucolyte-2 containing zinc and other electrolytes will be more favorable than the conventional infusion in both surgical and trauma patients.
为研究一种新型电解质溶液Glucolyte - 2的有效性，该溶液含有7.5%的葡萄糖、电解质和一种微量元素（锌），对12名术后无法接受肠内营养的外科患者和21名创伤患者采用双盲法，分别给予Glucolyte - 2或含5%葡萄糖和电解质的传统输液作为对照。接受Glucolyte - 2的外科患者锌平衡为2.648±864微克/天，而接受传统输液的患者锌平衡为 - 2972±1385微克/天（均值±标准误）。给予Glucolyte - 2后锌的正平衡显著高于传统输液后（p＜0.001）。同样，接受Glucolyte - 2的创伤患者锌平衡为正（3464±422微克/天），而接受传统输液的创伤患者锌平衡为负（ - 1737±491微克/天），且显著更低（p＜0.05）。两个输液组的外科和创伤患者镁和磷平衡均为负。然而，接受Glucolyte - 2的患者平衡情况优于接受传统输液的患者。外科患者和创伤患者镁平衡的差异显著（分别为p＜0.001和p＜0.01）。外科和创伤患者磷平衡的差异也显著（p＜0.01）。结果表明，输注含锌及其他电解质的Glucolyte - 2对外科和创伤患者均比传统输液更有利。
