Haave N C, Nicol L J, Innis S M
Department of Pathology, University of British Columbia, Vancouver, Canada.
J Nutr. 1990 Jun;120(6):539-43. doi: 10.1093/jn/120.6.539.
The effects of diets containing 20% (wt/wt) safflower, olive or palm oil or 5% (wt/wt) safflower oil when fed throughout gestation on hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity and on plasma and liver lipids were studied in fetal rats at d 21 of gestation. Hepatic total and active HMG CoA reductase activity, plasma free cholesterol and liver triglyceride and phospholipid 18:2(n-6) levels were higher in fetuses of rats fed 20% than in those of rats fed 5% safflower oil. Fetuses of rats fed olive oil had higher active HMG CoA reductase levels than fetuses of rats fed 20% safflower or palm oil; their total reductase activity was similar to that of the safflower oil group and higher than that for the palm oil group. Fetal liver and plasma cholesterol and triglyceride, as well as liver phospholipid concentrations, were not altered by the type of oil fed. The diets containing safflower oil resulted in higher 18:2(n-6) and lower 18:1 levels in fetal liver phospholipid and triglycerides than did the diets containing palm or olive oil. These studies demonstrate that fetal liver HMG CoA reductase activity is influenced by the maternal diet fat content and composition although the effect of specific fatty acids is unknown.
研究了在整个妊娠期喂食含20%（重量/重量）红花油、橄榄油或棕榈油的日粮，或含5%（重量/重量）红花油的日粮，对妊娠第21天胎鼠肝脏3-羟基-3-甲基戊二酰辅酶A（HMG CoA）还原酶活性以及血浆和肝脏脂质的影响。喂食20%红花油的大鼠所产胎鼠的肝脏总HMG CoA还原酶活性和活性HMG CoA还原酶活性、血浆游离胆固醇、肝脏甘油三酯以及磷脂18:2(n-6)水平，高于喂食5%红花油的大鼠所产胎鼠。喂食橄榄油的大鼠所产胎鼠的活性HMG CoA还原酶水平，高于喂食20%红花油或棕榈油的大鼠所产胎鼠；其总还原酶活性与红花油组相似，高于棕榈油组。所喂油的类型未改变胎鼠肝脏和血浆中的胆固醇、甘油三酯以及肝脏磷脂浓度。与含棕榈油或橄榄油的日粮相比，含红花油的日粮使胎鼠肝脏磷脂和甘油三酯中的18:2(n-6)水平升高，18:1水平降低。这些研究表明，尽管特定脂肪酸的作用尚不清楚，但胎鼠肝脏HMG CoA还原酶活性受母体日粮脂肪含量和组成的影响。
