Pinder M, Leclerc A, Flockhart H A, Egwang T G
Department of Immunoparasitology, Centre International de Recherches Médicales de Franceville, Gabon.
J Parasitol. 1990 Jun;76(3):373-6.
The ability of the filarial nematode Loa loa to infect 2 species of primates was studied. The primate species selected were closely related to species known to be susceptible. A mandrill (Mandrillus sphinx) and 6 cynomolgus monkeys (Macaca fascularis) were infected by subcutaneous injection of third-stage larvae of human L. loa from Gabon. The mandrill developed microfilaremia with an estimated prepatent period of 147 days, but microfilariae were not detected in any of the cynomolgus monkeys. Thus, mandrills appear permissive to human L. loa, whereas cynomolgus monkeys are not. Serum antibody responses were examined on western blots of adult L. loa antigens. Preinfection sera from all animals gave no reactions, but, after infection, sera from cynomolgus monkeys reacted more intensely and with more antigens than mandrill sera. Antibodies were still detectable in cynomolgus monkeys 15 mo postinfection. These reactions were compared with those found using human infection sera. Reactions with the cynomolgus monkey sera resembled those found with resistant endemic and amicrofilaremic human sera.
对丝状线虫罗阿罗阿感染两种灵长类动物的能力进行了研究。所选的灵长类动物物种与已知易感物种密切相关。通过皮下注射来自加蓬的人源罗阿罗阿第三期幼虫，感染了一只山魈（Mandrillus sphinx）和6只食蟹猴（Macaca fascularis）。山魈出现了微丝蚴血症，估计潜伏期为147天，但在任何食蟹猴中均未检测到微丝蚴。因此，山魈似乎对人源罗阿罗阿易感，而食蟹猴则不易感。在罗阿罗阿成虫抗原的western印迹上检测血清抗体反应。所有动物的感染前血清均无反应，但感染后，食蟹猴血清的反应比山魈血清更强烈，且与更多抗原发生反应。感染后15个月，食蟹猴血清中仍可检测到抗体。将这些反应与使用人类感染血清所发现的反应进行了比较。食蟹猴血清的反应与抗性地方流行和无微丝蚴血症的人类血清的反应相似。
