对乙酰氨基酚对HIV感染患者齐多夫定代谢的影响。

The effect of acetaminophen on zidovudine metabolism in HIV-infected patients.

作者信息

Steffe E M, King J H, Inciardi J F, Flynn N F, Goldstein E, Tonjes T S, Benet L Z

机构信息

Division of Infectious Disease, University of California, Davis Medical Center, Sacramento 95817.

出版信息

J Acquir Immune Defic Syndr (1988). 1990;3(7):691-4.

PMID:2352121

Abstract

The concomitant administration of acetaminophen to HIV-positive patients receiving zidovudine (AZT) therapy has previously been thought to increase the likelihood of the toxicity of AZT due to increased serum levels, resulting from hypothesized metabolic competition. We measured serum AZT and metabolite levels by HPLC in HIV-infected patients taking regular doses of AZT with and without acetaminophen administration. In all patients, serum levels of AZT and the glucuronidated metabolite (GAZT) were similar with and without acetaminophen administration. AZT serum levels were not increased (p less than 0.05). We believe that the rationale for withholding acetaminophen from patients receiving AZT should be re-evaluated.

摘要

以前认为，在接受齐多夫定（AZT）治疗的HIV阳性患者中同时服用对乙酰氨基酚，由于假设的代谢竞争导致血清水平升高，会增加AZT毒性的可能性。我们通过高效液相色谱法（HPLC）测量了定期服用AZT且服用或未服用对乙酰氨基酚的HIV感染患者的血清AZT和代谢物水平。在所有患者中，服用和未服用对乙酰氨基酚时，AZT和葡萄糖醛酸化代谢物（GAZT）的血清水平相似。AZT血清水平没有升高（p小于0.05）。我们认为，对于接受AZT治疗的患者停用对乙酰氨基酚的理由应该重新评估。