突触前小泡释放调控突触后逆向信号转导。
Regulation of postsynaptic retrograde signaling by presynaptic exosome release.
机构信息
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
出版信息
Neuron. 2013 Mar 20;77(6):1039-46. doi: 10.1016/j.neuron.2013.01.013.
Abstract
Retrograde signals from postsynaptic targets are critical during development and plasticity of synaptic connections. These signals serve to adjust the activity of presynaptic cells according to postsynaptic cell outputs and to maintain synaptic function within a dynamic range. Despite their importance, the mechanisms that trigger the release of retrograde signals and the role of presynaptic cells in this signaling event are unknown. Here we show that a retrograde signal mediated by Synaptotagmin 4 (Syt4) is transmitted to the postsynaptic cell through anterograde delivery of Syt4 via exosomes. Thus, by transferring an essential component of retrograde signaling through exosomes, presynaptic cells enable retrograde signaling.
摘要
来自突触后靶标向的逆行信号在突触连接的发育和可塑性中至关重要。这些信号根据突触后细胞的输出调节突触前细胞的活性，并在动态范围内维持突触功能。尽管它们很重要，但触发逆行信号释放的机制以及突触前细胞在这种信号事件中的作用尚不清楚。在这里，我们表明，通过外泌体顺行递送来传递突触小泡 4（Syt4）的逆行信号传递到突触后细胞。因此，通过外泌体传递逆行信号的必需成分，突触前细胞能够进行逆行信号传递。
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