Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China.
Cancer Center, Peking University Third Hospital, Beijing, China.
Signal Transduct Target Ther. 2024 Aug 7;9(1):196. doi: 10.1038/s41392-024-01888-z.
Multicellular organisms are composed of diverse cell types that must coordinate their behaviors through communication. Cell-cell communication (CCC) is essential for growth, development, differentiation, tissue and organ formation, maintenance, and physiological regulation. Cells communicate through direct contact or at a distance using ligand-receptor interactions. So cellular communication encompasses two essential processes: cell signal conduction for generation and intercellular transmission of signals, and cell signal transduction for reception and procession of signals. Deciphering intercellular communication networks is critical for understanding cell differentiation, development, and metabolism. First, we comprehensively review the historical milestones in CCC studies, followed by a detailed description of the mechanisms of signal molecule transmission and the importance of the main signaling pathways they mediate in maintaining biological functions. Then we systematically introduce a series of human diseases caused by abnormalities in cell communication and their progress in clinical applications. Finally, we summarize various methods for monitoring cell interactions, including cell imaging, proximity-based chemical labeling, mechanical force analysis, downstream analysis strategies, and single-cell technologies. These methods aim to illustrate how biological functions depend on these interactions and the complexity of their regulatory signaling pathways to regulate crucial physiological processes, including tissue homeostasis, cell development, and immune responses in diseases. In addition, this review enhances our understanding of the biological processes that occur after cell-cell binding, highlighting its application in discovering new therapeutic targets and biomarkers related to precision medicine. This collective understanding provides a foundation for developing new targeted drugs and personalized treatments.
多细胞生物由多种细胞类型组成，这些细胞类型必须通过通信协调其行为。细胞间通讯（CCC）对于生长、发育、分化、组织和器官形成、维持和生理调节至关重要。细胞通过直接接触或使用配体-受体相互作用进行远距离通讯。因此，细胞通讯包含两个基本过程：细胞信号传导，用于产生和细胞间信号传递，以及细胞信号转导，用于接收和处理信号。解析细胞间通讯网络对于理解细胞分化、发育和代谢至关重要。首先，我们全面回顾了 CCC 研究的历史里程碑，然后详细描述了信号分子传递的机制以及它们介导的主要信号通路在维持生物功能方面的重要性。然后，我们系统地介绍了一系列由细胞通讯异常引起的人类疾病及其在临床应用中的进展。最后，我们总结了监测细胞相互作用的各种方法，包括细胞成像、基于邻近性的化学标记、机械力分析、下游分析策略和单细胞技术。这些方法旨在说明生物功能如何依赖于这些相互作用及其调节信号通路的复杂性，以调节包括组织稳态、细胞发育和疾病中的免疫反应在内的关键生理过程。此外，本综述增强了我们对细胞间结合后发生的生物学过程的理解，突出了其在发现与精准医学相关的新治疗靶点和生物标志物方面的应用。这种集体理解为开发新的靶向药物和个性化治疗提供了基础。
