Division of Cardiac Surgery, Department of Surgical Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
Ann Thorac Surg. 2013 Apr;95(4):e79-81. doi: 10.1016/j.athoracsur.2012.09.089.
The role of antibody-mediated rejection in acute and chronic rejection after lung transplantation is poorly understood. We report the case of a prior single-lung transplant recipient undergoing an acute antibody-mediated rejection isolated to her new, contralateral single-lung transplant. A 44-year-old woman 6 years after undergoing a single-lung transplant for idiopathic pulmonary fibrosis underwent a second single-lung transplant for bronchiolitis obliterans syndrome. Despite a negative crossmatch, she subsequently exhibited severe antibody-mediated rejection to her new allograft within 6 days of transplantation. The process of allograft sensitization is dynamic, and further study is warranted to better understand this process.
抗体介导的排斥反应在肺移植后急性和慢性排斥反应中的作用还不太清楚。我们报告了一例先前接受过单肺移植的患者，在新的对侧单肺移植中发生了急性抗体介导的排斥反应。一位 44 岁的女性，在因特发性肺纤维化接受单肺移植 6 年后，因闭塞性细支气管炎综合征接受了第二次单肺移植。尽管交叉配型阴性，但她在移植后 6 天内新移植物中出现了严重的抗体介导的排斥反应。同种异体致敏的过程是动态的，需要进一步的研究来更好地理解这个过程。
