Treatment of large lower genital tract condylomata acuminata with topical 5-fluorouracil.

Nineteen women with extensive condyloma acuminatum involvement of the lower female genital tract were treated with seven-day courses of topical 5-fluorouracil. The complete response rate was 68.4%. One patient completed only two courses; she underwent vaginal delivery after cryosurgical destruction of the remaining lesions. Her recurrent lesions in the immediate postpartum period were controlled with additional courses of topical 5-fluorouracil. Only one patient was totally unresponsive to treatment with topical 5-fluorouracil.