Behbahaninia Milad, Martirosyan Nikolay L, Georges Joseph, Udovich Joshua A, Kalani M Yashar S, Feuerstein Burt G, Nakaji Peter, Spetzler Robert F, Preul Mark C
Neurosurgery Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.
Clin Neurol Neurosurg. 2013 May;115(5):517-28. doi: 10.1016/j.clineuro.2013.02.019. Epub 2013 Mar 21.
A review of fluorescent imaging for intracranial neoplasms is presented. Complete resection of brain cancer is seldom possible because of the goal to preserve brain tissue and the inability to visualize individual infiltrative tumor cells. Verification of histology and identification of tumor invasion in macroscopically normal-appearing brain tissue determine prognosis after resection of malignant gliomas. Therefore, imaging modalities aim to facilitate intraoperative decision-making. Intraoperative fluorescent imaging techniques have the potential to enable precise histopathologic diagnosis and to detect tumor remnants in the operative field. Macroscopic fluorescence imaging is effective for gross tumor detection. Microscopic imaging techniques enhance the sensitivity of the macroscopic observations and provide real-time histological information. Further development of clinical grade fluorescent agents specifically targeting tumor cells could improve the diagnostic and prognostic yield of intraoperative imaging.
本文对颅内肿瘤的荧光成像进行了综述。由于要保留脑组织且无法可视化单个浸润性肿瘤细胞，因此很少能够完全切除脑癌。恶性胶质瘤切除术后的预后取决于组织学验证以及在宏观外观正常的脑组织中肿瘤浸润的识别。因此，成像方式旨在促进术中决策。术中荧光成像技术有潜力实现精确的组织病理学诊断并检测手术区域中的肿瘤残留。宏观荧光成像对大体肿瘤检测有效。微观成像技术提高了宏观观察的灵敏度并提供实时组织学信息。专门针对肿瘤细胞的临床级荧光剂的进一步开发可以提高术中成像的诊断和预后效果。
