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通过分子分析进行INLINE 盒式提取，快速识别脑肿瘤组织。

Inline cartridge extraction for rapid brain tumor tissue identification by molecular profiling.

机构信息

Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russian Federation.

Federal State Autonomous Institution «N.N. Burdenko National Scientific and Practical Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation.

出版信息

Sci Rep. 2019 Dec 12;9(1):18960. doi: 10.1038/s41598-019-55597-7.

DOI:10.1038/s41598-019-55597-7
PMID:31831871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6908710/
Abstract

The development of perspective diagnostic techniques in medicine requires efficient high-throughput biological sample analysis methods. Here, we present an inline cartridge extraction that facilitates the screening rate of mass spectrometry shotgun lipidomic analysis of tissue samples. We illustrate the method by its application to tumor tissue identification in neurosurgery. In perspective, this high-performance method provides new possibilities for the investigation of cancer pathogenesis and metabolic disorders.

摘要

医学中前瞻性诊断技术的发展需要高效的高通量生物样本分析方法。在这里，我们提出了一种在线盒式萃取方法，可提高组织样本质谱 shotgun 脂质组分析的筛选速度。我们通过将其应用于神经外科中的肿瘤组织鉴定来说明该方法。从前景来看，这种高性能方法为癌症发病机制和代谢紊乱的研究提供了新的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb52/6908710/d47fb5087cc6/41598_2019_55597_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb52/6908710/1bacc9cd745a/41598_2019_55597_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb52/6908710/96b8de9e4b1c/41598_2019_55597_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb52/6908710/bc840f326f81/41598_2019_55597_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb52/6908710/d47fb5087cc6/41598_2019_55597_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb52/6908710/1bacc9cd745a/41598_2019_55597_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb52/6908710/96b8de9e4b1c/41598_2019_55597_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb52/6908710/bc840f326f81/41598_2019_55597_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb52/6908710/d47fb5087cc6/41598_2019_55597_Fig4_HTML.jpg

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