Lefer D J, Lynch C D, Lapinski K C, Hutchins P M
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27103.
Microvasc Res. 1990 Mar;39(2):129-39. doi: 10.1016/0026-2862(90)90065-y.
Intrinsic rhythmic changes in the diameter of pial cerebral arterioles (30-70 microns) in anesthetized normotensive and hypertensive rats were assessed in vivo to determine if any significant differences exist between the two strains. All diameter measurements were analyzed using a traditional graphic analysis technique and a new frequency spectrum analysis technique known as the Prony Spectral Line Estimator. Graphic analysis of the data revealed that spontaneously hypertensive rats (SHR) possess a significantly greater fundamental frequency (5.57 +/- 0.28 cycles/min) of vasomotion compared to the control Wistar-Kyoto normotensive rats (WKY) (1.95 +/- 0.37 cycles/min). Furthermore, the SHR cerebral arterioles exhibited a significantly greater amplitude of vasomotion (10.07 +/- 0.70 microns) when compared to the WKY cerebral arterioles of the same diameter (8.10 +/- 0.70 microns). Diameter measurements processed with the Prony technique revealed that the fundamental frequency of vasomotion in SHR cerebral arterioles (6.14 +/- 0.39 cycles/min) was also significantly greater than that of the WKY cerebral arterioles (2.99 +/- 0.42 cycles/min). The mean amplitudes of vasomotion in the SHR and WKY strains obtained by the Prony analysis were found not to be statistically significant in contrast to the graphic analysis of the vasomotion amplitude of the arterioles. In addition, the Prony system was able to consistently uncover a very low frequency of vasomotion in both strains of rats that was typically less than 1 cycle/min and was not significantly different between the two strains. The amplitude of this slow frequency was also not significantly different between the two strains. The amplitude of the slow frequency of vasomotion (less than 1 cycle/min) was not different from the amplitude of the higher frequency (2-6 cycles/min) vasomotion by Prony or graphic analysis. These data suggest that a fundamental intrinsic defect exists in the spontaneously hypertensive rat that may contribute to the pathogenesis of hypertension in these animals.
在体内评估了麻醉状态下正常血压和高血压大鼠软脑膜脑动脉（30 - 70微米）直径的内在节律变化，以确定这两种品系之间是否存在任何显著差异。所有直径测量均使用传统的图形分析技术和一种称为 Prony 谱线估计器的新频谱分析技术进行分析。对数据的图形分析显示，与对照的Wistar - Kyoto正常血压大鼠（WKY）（1.95±0.37次/分钟）相比，自发性高血压大鼠（SHR）的血管运动基本频率（5.57±0.28次/分钟）显著更高。此外，与相同直径的WKY脑动脉（8.10±0.70微米）相比，SHR脑动脉的血管运动幅度（10.07±0.70微米）显著更大。用 Prony 技术处理的直径测量结果显示，SHR脑动脉的血管运动基本频率（6.14±0.39次/分钟）也显著高于WKY脑动脉（2.99±0.42次/分钟）。与对小动脉血管运动幅度的图形分析相反，通过 Prony 分析获得的SHR和WKY品系血管运动的平均幅度在统计学上无显著差异。此外，Prony 系统能够始终发现两种品系大鼠中血管运动的一个非常低的频率，该频率通常低于1次/分钟，并且在两种品系之间无显著差异。两种品系之间这种缓慢频率的幅度也无显著差异。通过 Prony 或图形分析，血管运动缓慢频率（低于1次/分钟）的幅度与较高频率（2 - 6次/分钟）血管运动的幅度没有差异。这些数据表明，自发性高血压大鼠存在一种基本的内在缺陷，这可能导致这些动物高血压的发病机制。
