Raidis P C, Papadimitriou M, Metaxas P, Valtis D J
Proc Eur Dial Transplant Assoc. 1977;14:200-6.
Changes in the haemoglobin-oxygen dissociation curve (Hb-O2) and the factors which influence its position were studied before and after dialysis in 7 patients on regular haemodialysis during 20 dialyses. Seven normal subjects were used as controls. Haemoglobin showed a lower than normal affinity for O2 in uraemic patients before haemodialysis (p50in vivo = 33.09 +/- 0.92 mmHg and p507.4 = 31.51 +/- 0.73 mmHg, P less than 0.001), and this could be considered as a protection against tissue anoxia. After dialysis Hb-O2 affinity at the patient's pH (p50 in vivo = 27.97 +/- 0.57 mmHg, P less than 0.001). This probably eliminates the benefits of the predialysis balance of tissue oxygenation, producing a degree of hypoxia, and may play a role in the genesis of post-dialysis symptoms. Measures should be taken to improve oxygenation of high risk patients with latent heart failure or respiratory disturbances during and after dialysis.
对7例接受定期血液透析的患者在20次透析过程中透析前后的血红蛋白-氧解离曲线（Hb-O2）变化及其影响因素进行了研究。选取7名正常受试者作为对照。尿毒症患者透析前血红蛋白对氧的亲和力低于正常水平（体内p50 = 33.09±0.92 mmHg，pH7.4时p50 = 31.51±0.73 mmHg，P＜0.001），这可被视为对组织缺氧的一种保护。透析后，在患者的pH值下，Hb-O2亲和力（体内p50 = 27.97±0.57 mmHg，P＜0.001）。这可能消除了透析前组织氧合平衡的益处，产生一定程度的缺氧，并可能在透析后症状的发生中起作用。对于透析期间及透析后有潜在心力衰竭或呼吸障碍的高危患者，应采取措施改善其氧合情况。
