Meytes D, Shacked N, Blum M, Ramot B
Department of Hematology, Edith Wolfson Hospital, Holon, Israel.
Nephron. 1990;55(1):6-9. doi: 10.1159/000185910.
Patients with uremia have excess levels of parathyroid hormone (PTH). It has been reported that excess PTH is associated with bone marrow fibrosis. The present study was undertaken to examine the in vitro effect of intact 1-34 PTH and the active 1-34 N-terminal fragment on human bone-marrow-derived fibroblasts. Proliferation of fibroblasts was not stimulated by PTH in concentrations present in uremia (5-30 U/ml) nor by uremic sera which contained either high or low PTH levels. The lack of stimulation contrasted with the activity of both PTH preparations in other systems, i.e., inhibitory to erythroid colonies and stimulatory to heart muscle cells.
尿毒症患者甲状旁腺激素（PTH）水平过高。据报道，过量的PTH与骨髓纤维化有关。本研究旨在检测完整的1-34 PTH和活性1-34 N端片段对人骨髓来源成纤维细胞的体外作用。尿毒症患者体内存在的PTH浓度（5-30 U/ml）以及含有高或低PTH水平的尿毒症血清均未刺激成纤维细胞的增殖。这种缺乏刺激的情况与两种PTH制剂在其他系统中的活性形成对比，即在其他系统中，PTH对红系集落具有抑制作用，对心肌细胞具有刺激作用。
