Jurna Ilmar, Brune Kay
Institut für Pharmakologie und Toxikologie, Universität des Saarlandes, D-6650 Homburg/ SaarF.R.G. Institut für Pharmakologie und Toxikologie, Universität Nürnberg-Erlangen, D-8520 ErlangenF.R.G.
Pain. 1990 Apr;41(1):71-80. doi: 10.1016/0304-3959(90)91111-U.
This study aimed to investigate if the non-steroid anti-inflammatory agents, indomethacin, ibuprofen, and diclofenac, are capable of depressing sensory responses of the nociceptive system by a central action. For this purpose, experiments were carried out on rats under urethane anaesthesia in which activity was elicited by electrical stimulation of afferent C fibres in the sural nerve. Recordings were made ipsi- or contralaterally from single neurones in the dorsomedial part of the ventral nucleus (VDM) of the thalamus. The 3 drugs produced a dose-dependent depression of the evoked activity which amounted to about 60% of the controls at the highest doses employed and lasted longer than 60 min. Their potency ranking, according to the ED50 values (in brackets), is: indomethacin (5 mg/kg) greater than diclofenac (10.9 mg/kg) greater than ibuprofen (15.6 mg/kg). The results suggest that a central action might contribute to the analgesia produced by these non-steroid anti-inflammatory agents.
本研究旨在调查非甾体抗炎药吲哚美辛、布洛芬和双氯芬酸是否能够通过中枢作用抑制伤害性感受系统的感觉反应。为此，在乌拉坦麻醉的大鼠身上进行了实验，通过电刺激腓肠神经中的传入C纤维来引发活动。记录来自丘脑腹侧核背内侧部分（VDM）单个神经元的同侧或对侧活动。这三种药物产生了剂量依赖性的诱发活动抑制，在所用的最高剂量下，抑制程度达到对照组的约60%，且持续时间超过60分钟。根据半数有效剂量（ED50）值（括号内），它们的效力排序为：吲哚美辛（5毫克/千克）大于双氯芬酸（10.9毫克/千克）大于布洛芬（15.6毫克/千克）。结果表明，中枢作用可能有助于这些非甾体抗炎药产生镇痛效果。
