Institute of Physics, Chemistry and Pharmacy, University of Southern Denmark , Odense M , Denmark and.
Pharm Dev Technol. 2014 May;19(3):326-32. doi: 10.3109/10837450.2013.778875. Epub 2013 Mar 26.
The particularity of the Nano Spray Dryer B-90 is the nozzle containing a mesh vibrating at ultrasonic frequency.
To study process parameters and processability of crude phospholipid dispersions, in particular the effect of concentration and mesh aperture on both particle size of the dry solid phospholipid nano-particles and on the re-dispersed powder.
Phospholipid dispersions containing trehalose as a stabilizer were spray dried. Particle size distributions of dry powders were evaluated by SEM micrographs and by PCS and cryo-TEM for the re-dispersed particles.
Spray drying of crude liposome dispersions revealed solid phospholipid nano-particles. Aperture of nozzle mesh and concentration of the dispersions, respectively, both increased the size of solid phospholipid nano-particles. For crude dispersions, an upper limit with respect to processability was found close to below 10% (m/m) even if the crude dispersion was passed along the mesh several times; however, more effective dispersing methods such as pre-sonication can push the limit of processability to higher values.
The nano spray dryer is capable of spray drying crude dispersions of phospholipids in concentrations below 10% (m/m) generating solid phospholipid nano-particles relevant for pulmonary delivery. Re-dispersion of spray dried powder reveals liposomes.
Nano Spray Dryer B-90 的特殊性在于其喷嘴内含有一个以超声波频率振动的网孔。
研究粗磷脂分散体的工艺参数和可加工性，特别是浓度和网孔孔径对干燥固体磷脂纳米颗粒的粒径以及再分散粉末的影响。
用海藻糖作为稳定剂喷雾干燥磷脂分散体。通过 SEM 显微照片、PCS 和冷冻透射电镜评估干粉的粒径分布，以评估再分散颗粒。
喷雾干燥粗脂质体分散体得到固体磷脂纳米颗粒。喷嘴网孔的孔径和分散体的浓度都增加了固体磷脂纳米颗粒的尺寸。对于粗分散体，即使粗分散体通过网孔几次，也发现了接近 10%（m/m）以下的加工上限；然而，更有效的分散方法，如预超声，可以将加工上限推高到更高的值。
纳米喷雾干燥器能够在低于 10%（m/m）的浓度下喷雾干燥磷脂粗分散体，生成适用于肺部给药的固体磷脂纳米颗粒。喷雾干燥粉末的再分散揭示了脂质体。
