Uzun Hakki, Oğullar Sabri, Ünal Hüseyin, Zorba Orhan Ünal, Yazar Selim, Kalkan Mehmet
Department of Urology, School of Medicine, Recep Tayyip Erdoğan University , Rize , Turkey.
Scand J Urol. 2013 Dec;47(6):497-502. doi: 10.3109/21681805.2013.780258. Epub 2013 Mar 26.
Metabolic syndrome plays a significant role in the development of benign prostate hyperplasia (BPH) and overactive bladder (OAB). Non-alcoholic fatty liver disease (NAFLD) is accepted as the hepatic component of metabolic syndrome. This study investigated the association of NAFLD with BPH and OAB.
In total, 702 men with BPH and 529 women with and without OAB were recruited into the study in a cross-sectional risk factor analysis. All male and female patients were separated into two groups, with or without NAFLD. An overnight fasting blood profile was obtained and whole abdominal ultrasound was performed by a blinded radiologist in each patient to measure hepatic steatosis.
NAFLD was diagnosed in 387 (55.8%) of 702 men with BPH. Statistically significantly higher prostate volumes were found in men with NAFLD in comparison to without (p = 0.018). The female population included 207 women with NAFLD and 322 women without. OAB was found in 75.8% and 52.4% of women with and without NAFLD (p = 0.022).
NAFLD is associated with BPH in men and with OAB in women. These findings confirm the hypothesis that BPH is an aspect of the metabolic syndrome and support the hypothesis that OAB is an aspect of the metabolic syndrome.
代谢综合征在良性前列腺增生（BPH）和膀胱过度活动症（OAB）的发展中起重要作用。非酒精性脂肪性肝病（NAFLD）被认为是代谢综合征的肝脏组成部分。本研究调查了NAFLD与BPH和OAB之间的关联。
在一项横断面危险因素分析中，共招募了702名患有BPH的男性和529名患有或未患有OAB的女性参与研究。所有男性和女性患者被分为两组，有或没有NAFLD。获取过夜空腹血液检查结果，并由一名不知情的放射科医生对每位患者进行全腹部超声检查以测量肝脂肪变性。
702名患有BPH的男性中，387名（55.8%）被诊断为NAFLD。与未患NAFLD的男性相比，患NAFLD的男性前列腺体积在统计学上显著更大（p = 0.018）。女性人群包括207名患有NAFLD的女性和322名未患NAFLD的女性。患有和未患有NAFLD的女性中，OAB的发生率分别为75.8%和52.4%（p = 0.022）。
NAFLD与男性的BPH以及女性的OAB相关。这些发现证实了BPH是代谢综合征的一个方面这一假设，并支持了OAB是代谢综合征的一个方面这一假设。
