Zemková H, Teisinger J, Almon R R, Vejsada R, Hník P, Vyskocil F
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Pflugers Arch. 1990 Apr;416(1-2):126-9. doi: 10.1007/BF00370233.
Wet mass, resting membrane potential, frequency of miniature end-plate potentials and the concentration of [3H]ouabain-binding sites were studied after 7 days' immobilization of the rat soleus and extensor digitorum longus (EDL) muscles in the shortened or stretched position and after 3 and 7 days of remobilization. We observed that the loss of muscle mass by 37% in the rat soleus immobilized for 7 days in the shortened position is accompanied by a membrane depolarization of about 5 mV, a decrease in frequency of miniature end-plate potentials by 60% and a decrease of [3H]ouabain binding by 25%. Only minor changes were found in stretched soleus and in shortened and stretched EDL. After 3 days of remobilization of stretched soleus the muscle mass, [3H]ouabain binding and miniature end-plate potential frequency recovered to control values but the resting membrane potential continued to decrease. All changes induced by immobilization disappeared on day 7 of remobilization.
