Alifirova V M, Musina N F
Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(2 Pt 2):57-60.
Multiple sclerosis (MS) is an autoimmune disease of CNS characterized by myelin destruction and axonal damage. An aim of the study was to analyze the results of neuropsychological tests, cognitive evoked potentials P300 and to evaluate a role of brain atrophy in MS. Neurocognitive functions have been studied in 109 patients with MS. To study cognitive functions, we used the Mini-Mental State Examination (MMSE), the frontal assessment battery, the procedure developed by A.R. Luriya, cognitive evoked potentials P300. Magnetic resonance imaging data were analyzed in 71 patients. Correlations between cognitive functions, the activity of the disease and the expression of brain atrophy were found.
多发性硬化症（MS）是一种中枢神经系统的自身免疫性疾病，其特征为髓鞘破坏和轴突损伤。本研究的目的是分析神经心理学测试结果、认知诱发电位P300，并评估脑萎缩在MS中的作用。对109例MS患者的神经认知功能进行了研究。为研究认知功能，我们使用了简易精神状态检查表（MMSE）、额叶评估量表、A.R. 卢里亚开发的程序、认知诱发电位P300。对71例患者的磁共振成像数据进行了分析。发现了认知功能、疾病活动度和脑萎缩表现之间的相关性。
