Division of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden.
J Neuroimmunol. 2013 May 15;258(1-2):91-5. doi: 10.1016/j.jneuroim.2013.02.017. Epub 2013 Mar 23.
Peripheral immunization, using a combination of interferon-gamma (IFNγ)- and interleukin-7 (IL-7)-producing tumor cells, eradicated 75% of pre-established intracerebral N32 rat glioma tumors, and prolonged survival in the more aggressive RG2 model. Rats immunized with IFNγ- and IL7-transduced N32 cells displayed increases in IFNγ plasma levels and proliferating circulating T cells when compared with rats immunized with N32-wild type cells. Following irradiation, the expression of MHC I and II was high on N32-IFNγ cells, but low on RG2-IFNγ cells. In conclusion, IFNγ and IL-7 immunizations prolong survival in two rat glioma models.
外周免疫，使用干扰素-γ (IFNγ) -和白细胞介素-7 (IL-7) -产生的肿瘤细胞的组合，根除了 75%的预先建立的脑内 N32 大鼠神经胶质瘤肿瘤，并延长了更具侵袭性的 RG2 模型的存活时间。与用 N32 野生型细胞免疫的大鼠相比，用 IFNγ 和 IL7 转导的 N32 细胞免疫的大鼠显示 IFNγ 血浆水平和循环增殖 T 细胞增加。照射后，N32-IFNγ 细胞上 MHC I 和 II 的表达较高，而 RG2-IFNγ 细胞上的表达较低。总之，IFNγ 和 IL-7 免疫延长了两种大鼠神经胶质瘤模型的存活时间。
