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Growth hormone in health and disease: Long-term GH therapy--benefits and unanswered questions.

作者信息

Clemmons David

出版信息

Nat Rev Endocrinol. 2013 Jun;9(6):317-8. doi: 10.1038/nrendo.2013.68. Epub 2013 Mar 26.

DOI:10.1038/nrendo.2013.68
PMID:23529042
Abstract
摘要

相似文献

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Growth hormone in health and disease: Long-term GH therapy--benefits and unanswered questions.健康与疾病中的生长激素：长期生长激素治疗——益处与未解问题。
Nat Rev Endocrinol. 2013 Jun;9(6):317-8. doi: 10.1038/nrendo.2013.68. Epub 2013 Mar 26.
2
Fifteen years of GH replacement improves body composition and cardiovascular risk factors.15 年的 GH 替代治疗可改善身体成分和心血管危险因素。
Eur J Endocrinol. 2013 Apr 15;168(5):745-53. doi: 10.1530/EJE-12-1083. Print 2013 May.
3
[Efficacy, safety and compliance of long-term growth hormone (GH) replacement therapy in adults with GH deficiency].生长激素（GH）缺乏症成人长期替代治疗的疗效、安全性及依从性
Arq Bras Endocrinol Metabol. 2008 Jul;52(5):879-88. doi: 10.1590/s0004-27302008000500021.
4
Growth hormone decreases visceral fat and improves cardiovascular risk markers in women with hypopituitarism: a randomized, placebo-controlled study.生长激素可减少垂体功能减退女性的内脏脂肪并改善心血管风险指标：一项随机、安慰剂对照研究。
J Clin Endocrinol Metab. 2008 Jun;93(6):2063-71. doi: 10.1210/jc.2007-2371. Epub 2008 Apr 1.
5
[Growth hormone deficiency in adults: effects of replacement therapy on body composition and health-related quality of life].成人生长激素缺乏症：替代疗法对身体成分及健康相关生活质量的影响
Med Clin (Barc). 2003 Jan 25;120(2):41-6. doi: 10.1016/s0025-7753(03)73599-4.
6
Effect of long-term GH replacement therapy on cardiovascular outcomes in isolated GH deficiency compared with multiple pituitary hormone deficiencies: a sub-analysis from the Dutch National Registry of Growth Hormone Treatment in Adults.长期 GH 替代治疗对孤立性 GH 缺乏症与多种垂体激素缺乏症患者心血管结局的影响：来自荷兰成人 GH 治疗国家注册库的一项亚分析。
Eur J Endocrinol. 2014 Aug;171(2):151-60. doi: 10.1530/EJE-14-0069. Epub 2014 May 6.
7
Growth hormone replacement therapy improves body composition and increases bone metabolism in elderly patients with pituitary disease.生长激素替代疗法可改善垂体疾病老年患者的身体成分并增加骨代谢。
J Clin Endocrinol Metab. 2000 Nov;85(11):4104-12. doi: 10.1210/jcem.85.11.6949.
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Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women.雷洛昔芬和雌激素对生长激素替代治疗的垂体功能减退妇女身体成分的影响。
J Clin Endocrinol Metab. 2012 Mar;97(3):1005-12. doi: 10.1210/jc.2011-2837. Epub 2011 Dec 14.
9
Long-term effects of growth hormone therapy on intermediary metabolism and insulin sensitivity in hypopituitary adults.生长激素治疗对垂体功能减退成人患者中间代谢及胰岛素敏感性的长期影响。
J Endocrinol Invest. 1999;22(5 Suppl):37-40.
10
Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status--3-year results from the HypoCCS Database.成年垂体功能减退患者的生长激素替代治疗：对身体成分和血脂状况的长期影响——来自HypoCCS数据库的3年结果
J Clin Endocrinol Metab. 2002 Apr;87(4):1600-6. doi: 10.1210/jcem.87.4.8429.

本文引用的文献

1
Fifteen years of GH replacement improves body composition and cardiovascular risk factors.15 年的 GH 替代治疗可改善身体成分和心血管危险因素。
Eur J Endocrinol. 2013 Apr 15;168(5):745-53. doi: 10.1530/EJE-12-1083. Print 2013 May.
2
Fifteen years of GH replacement increases bone mineral density in hypopituitary patients with adult-onset GH deficiency.十五年的 GH 替代治疗可增加成人 GH 缺乏性垂体功能减退患者的骨密度。
Eur J Endocrinol. 2012 May;166(5):787-95. doi: 10.1530/EJE-11-1072. Epub 2012 Feb 8.
3
Does pituitary radiotherapy increase the risk of stroke and, if so, what preventative actions should be taken?
垂体放疗是否会增加中风的风险？如果是，应该采取哪些预防措施？
Clin Endocrinol (Oxf). 2012 Mar;76(3):328-31. doi: 10.1111/j.1365-2265.2011.04300.x.
4
Mortality in patients with pituitary disease.垂体疾病患者的死亡率。
Endocr Rev. 2010 Jun;31(3):301-42. doi: 10.1210/er.2009-0033. Epub 2010 Jan 19.
5
Occurrence of impaired fasting glucose in GH-deficient adults receiving GH replacement compared with untreated subjects.生长激素缺乏症患者接受生长激素替代治疗后出现空腹血糖受损的情况与未治疗的患者相比。
Clin Endocrinol (Oxf). 2010 Jan;72(1):59-69. doi: 10.1111/j.1365-2265.2009.03612.x. Epub 2009 May 4.
6
Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects.生长激素对人体葡萄糖、脂质和蛋白质代谢的影响。
Endocr Rev. 2009 Apr;30(2):152-77. doi: 10.1210/er.2008-0027. Epub 2009 Feb 24.
7
Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis.2589例垂体功能减退性生长激素缺乏成人患者心血管风险的决定因素——一项KIMS数据库分析
Eur J Endocrinol. 2006 Jul;155(1):79-90. doi: 10.1530/eje.1.02179.
8
Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status--3-year results from the HypoCCS Database.成年垂体功能减退患者的生长激素替代治疗：对身体成分和血脂状况的长期影响——来自HypoCCS数据库的3年结果
J Clin Endocrinol Metab. 2002 Apr;87(4):1600-6. doi: 10.1210/jcem.87.4.8429.
9
Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure.生长激素治疗腹部肥胖男性可减少腹部脂肪量，改善葡萄糖和脂蛋白代谢，并降低舒张压。
J Clin Endocrinol Metab. 1997 Mar;82(3):727-34. doi: 10.1210/jcem.82.3.3809.
10
Factors influencing the desire for long-term growth hormone replacement in adults.影响成人长期生长激素替代治疗意愿的因素。
Clin Endocrinol (Oxf). 1995 Aug;43(2):151-7. doi: 10.1111/j.1365-2265.1995.tb01909.x.