Gstaiger Matthias, Aebersold Ruedi
Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Mol Biosyst. 2013 Jun;9(6):1064-7. doi: 10.1039/c3mb25583b. Epub 2013 Mar 26.
Recent progress in genomic sequencing has revealed genotype-phenotype information of enormous complexity and challenges earlier hypotheses on how phenotypes emerge from altered gene structures. The field of proteomics has advanced in parallel and offers promising new concepts for a modern interpretation of complex and nonlinear genotype-phenotype relationships. We are beginning to decipher global proteome organization with increasing throughput and accuracy. These efforts revealed a highly modular organization of the protein landscape. Here we discuss the challenges and implications emerging from a modular protein landscape for a better understanding of complex genotype-phenotype patterns.
基因组测序的最新进展揭示了基因型-表型信息的巨大复杂性，对早期关于表型如何从改变的基因结构中产生的假设提出了挑战。蛋白质组学领域也在同步发展，并为现代诠释复杂的非线性基因型-表型关系提供了有前景的新概念。我们正开始以越来越高的通量和准确性来解读全球蛋白质组的组织情况。这些研究揭示了蛋白质景观的高度模块化组织。在此，我们讨论模块化蛋白质景观所带来的挑战及其影响，以便更好地理解复杂的基因型-表型模式。
