Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio, USA.
Nutr Cancer. 2013;65(3):329-44. doi: 10.1080/01635581.2013.767367.
The prophylactic and therapeutic properties of tea have been attributed to green tea catechins and black tea theaflavins besides several other polyphenolic compounds. Tea polyphenols possess potent antioxidant and antiinflammatory properties and modulate several signaling pathways. These biochemical facets of tea polyphenols are responsible for its anticancer properties. Several lethal cancers, such as liver cancer, develop within a background of oxidative stress and inflammation. Liver cancer, also known as hepatocellular carcinoma (HCC), has been shown to occur throughout the world including Asia, Africa, Western Europe, and the United States. Phytochemicals, such as tea polyphenols, provide an effective and promising alternative for the chemoprevention and treatment of HCC. In this article, we systematically review, for the first time, the effects of tea polyphenols in the preclinical in vitro and in vivo HCC models. The review also examines, in critical detail, the biochemical mechanisms involved in the chemopreventive and antineoplastic effects of tea polyphenols in hepatic cancer. Finally, we highlight the role of synergy, bioavailability and pharmacokinetics of tea polyphenols, current status of clinical trials, discuss future directions, and comment on the future challenges involved in the effective use of tea polyphenols for the prevention and management of liver cancer.
茶的预防和治疗特性归因于绿茶儿茶素和红茶茶黄素，以及其他几种多酚化合物。茶多酚具有强大的抗氧化和抗炎特性，并调节几种信号通路。这些茶多酚的生化方面是其抗癌特性的原因。几种致命的癌症，如肝癌，是在氧化应激和炎症的背景下发展起来的。肝癌，也称为肝细胞癌 (HCC)，已在包括亚洲、非洲、西欧和美国在内的世界各地发生。植物化学物质，如茶多酚，为 HCC 的化学预防和治疗提供了一种有效且有前途的替代方法。在本文中，我们首次系统地综述了茶多酚在 HCC 的临床前体外和体内模型中的作用。该综述还详细检查了茶多酚在肝癌的化学预防和抗肿瘤作用中涉及的生化机制。最后，我们强调了茶多酚协同作用、生物利用度和药代动力学的作用、临床试验的现状、讨论未来的方向，并评论了有效使用茶多酚预防和管理肝癌所涉及的未来挑战。
