Seegenschmiedt M H, Sauer R, Fietkau R, Karlsson U L, Brady L W
Department of Radiation Oncology, University of Erlangen-Nürnberg, Federal Republic of Germany.
Radiology. 1990 Jul;176(1):267-74. doi: 10.1148/radiology.176.1.2353100.
Thirty-seven patients with 18 primary advanced or persistent, 16 local recurrent, and three local metastatic tumors of the head and neck were treated with a combination of interstitial low-dose iridium-192 radiation therapy and interstitial 915-MHz microwave hyperthermia supplemented by external radiation therapy. Twenty-eight lesions received an additional external radiation dose of 21-61 Gy. Interstitial hyperthermia was applied immediately before Ir-192 was placed and after its removal for 45-60 minutes at 41 degrees C-44 degrees C. Follow-up ranged from 4 to 45 months. At 3 months, complete remission occurred in 25 lesions (68%); partial remission, in nine (24%); and no change or progressive disease, in three (8%). At 12 months of follow-up in 32 lesions, local control was achieved in 23 (72%), with the patients alive, and in four (12%), with the patients dead. There were five local recurrences, one of which occurred after complete response. Lesion type, tumor volume, radiation dose, and thermal quality at high minimum temperature were identified as prognostic factors influencing complete remission. The combined treatment was well tolerated.
37例头颈部原发性晚期或持续性肿瘤18例、局部复发性肿瘤16例、局部转移性肿瘤3例患者，接受了组织间低剂量铱-192放射治疗与组织间915兆赫微波热疗联合外部放射治疗。28个病灶额外接受了21 - 61戈瑞的外部放射剂量。在放置铱-192之前及取出后立即进行组织间热疗，在41℃ - 44℃下持续45 - 60分钟。随访时间为4至45个月。3个月时，25个病灶（68%）完全缓解；9个病灶（24%）部分缓解；3个病灶（8%）无变化或疾病进展。在对32个病灶进行12个月的随访时，23个病灶（72%）实现了局部控制，患者存活；4个病灶（12%）实现了局部控制，但患者死亡。有5例局部复发，其中1例发生在完全缓解之后。病灶类型、肿瘤体积、放射剂量以及最低高温时的热质量被确定为影响完全缓解的预后因素。联合治疗耐受性良好。
