Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Department of Dermatology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 210042 Nanjing, China.
Acta Derm Venereol. 2013 Nov;93(6):711-4. doi: 10.2340/00015555-1595.
Mycobacterium intracellulare-caused pulmonary infections have mostly been reported in immunocompromised hosts, while cutaneous M. intracellulare infections are rare. We describe here an immunocompetent patient with cutaneous lesions due to M. intracellulare, which was diagnosed by acid-fast staining, in vitro culture, histopathology, and PCR-restriction fragment length polymorphism analysis and gene sequencing of heat-shock protein (hsp) 65 and 16S rDNA genes. In vitro susceptibility testing was also carried out and the patient was successfully treated with clarithromycin, rifampicin, and ethambutol.
分枝杆菌属细胞内感染主要发生于免疫功能低下的宿主,而皮肤分枝杆菌属细胞内感染则较为罕见。我们在此描述了一例免疫功能正常的患者,其因分枝杆菌属细胞内感染而出现皮肤损伤,分枝杆菌属细胞内感染的诊断依据为抗酸染色、体外培养、组织病理学、聚合酶链反应-限制性片段长度多态性分析以及热休克蛋白 (hsp) 65 和 16S rDNA 基因的测序。体外药敏试验也进行了,患者成功地接受了克拉霉素、利福平、乙胺丁醇治疗。