Chin Calvin W, Gao F, Le Tt, Tan Rs
Department of Cardiology, National Heart Center Singapore, Singapore.
Clin Med Insights Cardiol. 2013;7:51-7. doi: 10.4137/CMC.S11488. Epub 2013 Mar 12.
Lipid goal attainment studies in Asian patients with acute coronary syndrome (ACS) are limited. The objectives of this study were to determine low-density lipoprotein cholesterol (LDL-C) goal attainment rate at 4 months, and to examine prescription behavior influencing lipid goal attainment in Asian patients with ACS. A retrospective analysis of 267 patients with ACS was performed. The mean follow-up duration was 41.2±10.7 months. LDL-C goal attainment rate was highest at 4 months (36.7%) but declined progressively throughout follow-up. More than 85% of patients were discharged with equipotent statin dose of 2 (equivalent to simvastatin 20 mg) or less. In patients who did not attain LDL-C goals, the statin dose remained low throughout follow-up because of a lack in responsive dose titration. Aggressive lipid-lowering therapy should be initiated early to improve goal attainment in these high-risk patients.
针对亚洲急性冠状动脉综合征（ACS）患者的血脂达标研究较为有限。本研究的目的是确定4个月时低密度脂蛋白胆固醇（LDL-C）的达标率，并探讨影响亚洲ACS患者血脂达标情况的处方行为。对267例ACS患者进行了回顾性分析。平均随访时间为41.2±10.7个月。LDL-C达标率在4个月时最高（36.7%），但在整个随访过程中逐渐下降。超过85%的患者出院时使用的等效他汀剂量为2（相当于辛伐他汀20毫克）或更低。在未达到LDL-C目标的患者中，由于缺乏有效的剂量滴定，整个随访过程中他汀剂量一直较低。应尽早开始积极的降脂治疗，以提高这些高危患者的达标率。
