Jadot G, Bussiere H, Mesdjian E, Valli M, Roger J
Service de Pharmacologie Clinique, Hôpital de la Timone, Marseille.
Therapie. 1990 Mar-Apr;45(2):151-5.
Little information is available on the effect produced by antiepileptic drugs on the serum beta-glucuronidase activity. According to recent findings, beta-glucuronidase serum levels are increased in patients with epilepsy just before the beginning of seizures and remain increased during several weeks; this it is suggested that determination of this enzyme could be important in the provision and the treatment of seizures. The purpose of the present study attempts to understand these changes. Our study was carried out on 49 adult healthy subjects and 48 adult epileptic patients receiving anticonvulsant therapies. Serum beta-glucuronidase activity was determined by a simplified procedure employing phenolphtalein glucuronic acid as substrate. The mean +/- SEM of serum beta-glucuronidase activity in treated patients (40.93 +/- 5.01 MSU/ml) was significantly higher than those of the healthy subjects (25.04 +/- 3.40 MSU/ml). In conclusion, the relationship between changes in serum enzyme activity, seizures and anticonvulsant therapies suggests that the determination of serum beta-glucuronidase activity presents a weak interest in predicting or treating seizures.
关于抗癫痫药物对血清β-葡萄糖醛酸酶活性产生的影响，目前可获取的信息较少。根据最近的研究结果，癫痫患者在癫痫发作开始前血清β-葡萄糖醛酸酶水平会升高，并在数周内持续升高；因此有人提出，测定这种酶对于癫痫的预防和治疗可能具有重要意义。本研究的目的是试图了解这些变化。我们的研究针对49名成年健康受试者和48名接受抗惊厥治疗的成年癫痫患者展开。血清β-葡萄糖醛酸酶活性通过采用酚酞葡萄糖醛酸作为底物的简化程序进行测定。接受治疗患者的血清β-葡萄糖醛酸酶活性平均值±标准误（40.93±5.01 MSU/ml）显著高于健康受试者（25.04±3.40 MSU/ml）。总之，血清酶活性变化、癫痫发作与抗惊厥治疗之间的关系表明，测定血清β-葡萄糖醛酸酶活性对于预测或治疗癫痫发作的意义不大。
